Article
Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion.
Molecular cancer - 13 Dec 2021
Cai Zhixiong, Su Xiaoping, Qiu Liman, Li Zhenli, Li Xiaolou, Dong Xiuqing, Wei Fuqun, Zhou Yang, Luo Liuping, Chen Geng, Chen Hengkai, Wang Yingchao, Zeng Yongyi, Liu Xiaolong
Abstract excerpt
BACKGROUND: Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely limited. Neoantigen based vaccine can generate robust anti-tumor immune response in several solid tumors but whether it could induce anti-tumor immune response in HCC and serve as a safe and effective prophylactic strategy for preventing postoperative HCC recurrence still...
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