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Human chromosome 3p21.3 carries TERT transcriptional regulators in pancreatic cancer

28 Jul 2021

Abstract excerpt

Frequent loss of heterozygosity (LOH) on the short arm of human chromosome 3 (3p) region has been found in pancreatic cancer (PC), which suggests the likely presence of tumor suppressor genes in this region. However, the functional significance of LOH in this region in the development of PC has not been clearly defined. The human telomerase reverse transcriptase gene (hTERT) contributes to unlimited proliferative...

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PMID: 34321527
DOI: 10.1038/s41598-021-94711-6

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