Article

Identification of TMEM115 as a tumor suppressor gene through TERT regulation in pancreatic cancer

2025-05-20

Abstract excerpt

<title>Abstract</title> The catalytic component of telomerase, telomerase reverse transcriptase (<italic>TERT</italic>), is reactivated in immortalized cells and plays a crucial role in cancer development. Pancreatic cancer (PC) is frequently associated with loss of heterozygosity on the short arm of human chromosome 3. In a previous study, chromosome engineering experiments in PC suggested that putative <ital...

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Literature Corpus work: b79f894b-cb87-54c4-888b-fcaf5760af84
DOI: 10.21203/rs.3.rs-6170448/v1

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