Prognostic impact of CEBPA mutational subgroups in adult AML.

doi:10.1038/s41375-024-02140-x

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Prognostic impact of CEBPA mutational subgroups in adult AML.

Leukemia - 1 Feb 2024

Georgi Julia-Annabell, Stasik Sebastian, Kramer Michael, Meggendorfer Manja, Röllig Christoph, Haferlach Torsten, Valk Peter, Linch David, Herold Tobias, Duployez Nicolas, Taube Franziska, Middeke Jan Moritz, Platzbecker Uwe, Serve Hubert, Baldus Claudia D, Muller-Tidow Carsten, Haferlach Claudia, Koch Sarah, Berdel Wolfgang E, Woermann Bernhard J, Krug Utz, Braess Jan, Hiddemann Wolfgang, Spiekermann Karsten, Boertjes Emma L, Hills Robert K, Burnett Alan, Ehninger Gerhard, Metzeler Klaus, Rothenberg-Thurley Maja, Dufour Annika, Dombret Hervé, Pautas Cecile, Preudhomme Claude, Fenwarth Laurene, Bornhäuser Martin, Gale Rosemary, Thiede Christian

Abstract excerpt

Despite recent refinements in the diagnostic and prognostic assessment of CEBPA mutations in AML, several questions remain open, i.e. implications of different types of basic region leucin zipper (bZIP) mutations, the role of co-mutations and the allelic state. Using pooled primary data analysis on 1010 CEBPA-mutant adult AML patients, a comparison was performed taking into account the type of mutation (bZIP:...

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PMID: 38228680
DOI: 10.1038/s41375-024-02140-x
PMCID: PMC10844079

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