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Article

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution.

Oncogene - 4 May 2017

Puccetti M V, Fischer M A, Arrate M P, Boyd K L, Duszynski R J, Bétous R, Cortez D, Eischen C M

Abstract excerpt

DNA replication stress promotes genome instability in cancer. However, the contribution of the replication stress response to the development of malignancies remains unresolved. The DNA replication stress response protein SMARCAL1 stabilizes DNA replication forks and prevents replication fork collapse, a cause of DNA breaks and apoptosis. While the fork regression/remodeling functions of SMARCAL1 have been...

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Share to DNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27797382
DOI: 10.1038/onc.2016.408
PMCID: PMC5562353

Genes

SMARCAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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