Article
PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.
JCI insight - 25 Mar 2021
Liotta Lucia, Lange Sebastian, Maurer H Carlo, Olive Kenneth P, Braren Rickmer, Pfarr Nicole, Burger Sebastian, Muckenhuber Alexander, Jesinghaus Moritz, Steiger Katja, Weichert Wilko, Friess Helmut, Schmid Roland, Algül Hana, Jost Philipp J, Ramser Juliane, Fischer Christine, Quante Anne S, Reichert Maximilian, Quante Michael
Abstract excerpt
BACKGROUNDPancreatic cancer is one of the deadliest cancers, with low long-term survival rates. Despite recent advances in treatment, it is important to identify and screen high-risk individuals for cancer prevention. Familial pancreatic cancer (FPC) accounts for 4%-10% of pancreatic cancers. Several germline mutations are related to an increased risk and might offer screening and therapy options. In this study,...
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