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Article

Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.

Molecular and cellular biology - 1 Jan 2013

van der Hoeven Dharini, Cho Kwang-jin, Ma Xiaoping, Chigurupati Sravanthi, Parton Robert G, Hancock John F

Abstract excerpt

Ras proteins regulate signaling pathways important for cell growth, differentiation, and survival. Oncogenic mutant Ras proteins are commonly expressed in human tumors, with mutations of the K-Ras isoform being most prevalent. To be active, K-Ras must undergo posttranslational processing and associate with the plasma membrane. We therefore devised a high-content screening assay to search for inhibitors of K-Ras...

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Identifiers

PMID: 23129805
DOI: 10.1128/MCB.00884-12
PMCID: PMC3554123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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