Article
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2007
Jin Hongchuan, Wang Xian, Ying Jianming, Wong Ada H Y, Cui Yan, Srivastava Gopesh, Shen Zhong-Ying, Li En-Min, Zhang Qian, Jin Jie, Kupzig Sabine, Chan Anthony T C, Cullen Peter J, Tao Qian
Abstract excerpt
Ras has achieved notoriety as an oncogene aberrantly activated in multiple human tumors. Approximately 30% of all human tumors express an oncogenic form of this GTPase that is locked in an active conformation as a result of being insensitive to Ras GTPase-activating proteins (GAPs), proteins that normally regulate the inactivation of Ras by enhancing its intrinsic GTPase activity. Besides oncogenic mutations in...
Topics
- Calcium
- Cell Line, Tumor
- Chromosomes, Human, Pair 12
- CpG Islands
- Down-Regulation
- Enzyme Activation
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans