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Article

Enhanced Fitness of a Helicobacter pylori babA Mutant in a Murine Model.

Infection and immunity - 16 Sept 2021

Harvey M Lorena, Lin Aung Soe, Sun Lili, Koyama Tatsuki, Shuman Jennifer H B, Loh John T, Algood Holly M Scott, Scholz Matthew B, McClain Mark S, Cover Timothy L

Abstract excerpt

Helicobacter pylori genomes encode over 60 predicted outer membrane proteins (OMPs). Several OMPs in the Hop family act as adhesins, but the functions of most Hop proteins are unknown. To identify hop mutant strains exhibiting differential fitness in vivo compared to in vitro, we used a genetic barcoding method that allowed us to track changes in the proportional abundance of H. pylori strains within a mixed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34310886
DOI: 10.1128/IAI.00725-20
PMCID: PMC8445181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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