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Article

RSPO1-mutated fibroblasts from non-tumoural areas of palmoplantar keratoderma display a cancer-associated phenotype.

European journal of dermatology : EJD - 1 Jun 2021

Dellambra Elena, Cordisco Sonia, Proto Vittoria, Nicodemi Ezio M, Didona Biagio, Cesario Claudia, Pisaneschi Elisa, Valente Carola, Teson Massimo, Castiglia Daniele, Guerra Liliana

Abstract excerpt

R-spondin (RSPO)1 is a fibroblast-secreted protein that belongs to the R-spondin protein family which is essential for reproductive organ development, epithelial stem cell renewal and cancer induction or suppression. RSPO1 gene mutations cause palmoplantar hyperkeratosis with squamous cell carcinoma (SCC) of the skin, 46XX sex reversal and true hermaphroditism. To characterize RSPO1-deficient skin fibroblasts...

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Identifiers

PMID: 34309520
DOI: 10.1684/ejd.2021.4066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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