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Epigenetic Mechanisms in DNA Double Strand Break Repair: A Clinical Review

7 Jul 2021

Abstract excerpt

Upon the induction of DNA damage, the chromatin structure unwinds to allow access to enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin occurs via epigenetic modifications, which can alter gene expression without changing the DNA sequence. Epigenetic mechanisms such as histone acetylation and DNA methylation are known to be reversible and have been indicated to play different...

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PMID: 34307454
DOI: 10.3389/fmolb.2021.685440

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