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Follow-up of tissue genomics in BRCA1/2 carriers who underwent prophylactic surgeries.

Breast cancer (Tokyo, Japan) - 1 Nov 2021

Kotoula Vassiliki, Papadopoulou Kyriaki, Tikas Ioannis, Fostira Florentia, Vrettou Eleni, Chrisafi Sofia, Fountzilas Elena, Koliou Georgia-Angeliki, Apostolou Paraskevi, Papazisis Konstantinos, Zaramboukas Thomas, Asimaki-Vlachopoulou Anthoula, Miliaras Spyros, Ananiadis Ananias, Poulios Christos, Natsiopoulos Ioannis, Tsiftsoglou Aris, Demiri Efterpi, Fountzilas George

Abstract excerpt

PURPOSE: The genomic status of non-malignant tissues from carriers of pathogenic germline BRCA1/2 (gBRCA1/2) variants may reveal information towards individualized prophylaxis. We performed spatiotemporal tissue genotype comparisons in a real-life cohort of gBRCA1/2 carriers of Greek origin, who underwent multiple risk-reducing/prophylactic surgeries at various time points. METHODS: Fifty-three women (median age...

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PMID: 34304347
DOI: 10.1007/s12282-021-01276-3

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