Article
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Nature communications - 30 Jan 2020
Liu Yi, Zhang Yuanyuan, Li Tong, Han Jinbo, Wang Yiguo
Abstract excerpt
Circadian clocks in the suprachiasmatic nucleus and peripheral tissues orchestrate behavioral and physiological activities of mammals in response to environmental cues. In the liver, the circadian clock is also modulated by feeding. However, the molecular mechanisms involved are unclear. Here, we show that TJP1 (tight junction protein 1) functions as a mediator of mTOR (mechanistic target of rapamycin) to...
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