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Article

Tight junctions, leaky intestines, and pediatric diseases

1 Apr 2005

Abstract excerpt

BACKGROUND: Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called "leaky gut") and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy. AIM: This review provides an overview of evidence for...

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PMID: 16092447
DOI: 10.1111/j.1651-2227.2005.tb01904.x

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