Article
KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2021
Salmón Marina, Paniagua Guillem, Lechuga Carmen G, Fernández-García Fernando, Zarzuela Eduardo, Álvarez-Díaz Ruth, Musteanu Monica, Guerra Carmen, Caleiras Eduardo, Muñoz Javier, Ortega Sagrario, Drosten Matthias, Barbacid Mariano
Abstract excerpt
In mammals, the KRAS locus encodes two protein isoforms, KRAS4A and KRAS4B, which differ only in their C terminus via alternative splicing of distinct fourth exons. Previous studies have shown that whereas KRAS expression is essential for mouse development, the KRAS4A isoform is expendable. Here, we have generated a mouse strain that carries a terminator codon in exon 4B that leads to the expression of an...
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