Article
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
JCI insight - 5 Nov 2020
Wong Jasmine C, Perez-Mancera Pedro A, Huang Tannie Q, Kim Jangkyung, Grego-Bessa Joaquim, Del Pilar Alzamora Maria, Kogan Scott C, Sharir Amnon, Keefe Susan H, Morales Carolina E, Schanze Denny, Castel Pau, Hirose Kentaro, Huang Guo N, Zenker Martin, Sheppard Dean, Klein Ophir D, Tuveson David A, Braun Benjamin S, Shannon Kevin
Abstract excerpt
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemically and functionally activated than those in cancer. We generated mice harboring conditional KrasLSL-P34Rand KrasLSL-T58I knock-in alleles and characterized the...
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