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Article

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.

Cancer discovery - 1 Dec 2021

Xu Jia, Yu Xufen, Martin Tiphaine C, Bansal Ankita, Cheung Kakit, Lubin Abigail, Stratikopoulos Elias, Cahuzac Kaitlyn M, Wang Li, Xie Ling, Zhou Royce, Shen Yudao, Wu Xuewei, Yao Shen, Qiao Ruifang, Poulikakos Poulikos I, Chen Xian, Liu Jing, Jin Jian, Parsons Ramon

Abstract excerpt

Using a panel of cancer cell lines, we characterized a novel degrader of AKT, MS21. In mutant PI3K-PTEN pathway cell lines, AKT degradation was superior to AKT kinase inhibition for reducing cell growth and sustaining lower signaling over many days. AKT degradation, but not kinase inhibition, profoundly lowered Aurora kinase B (AURKB) protein, which is known to be essential for cell division, and induced G2-M...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34301793
DOI: 10.1158/2159-8290.CD-20-0815
PMCID: PMC9056008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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