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Article

Essential roles of mTOR/Akt pathway in Aurora-A cell transformation.

International journal of biological sciences - 19 Jun 2009

Taga Makoto, Hirooka Eiji, Ouchi Toru

Abstract excerpt

We have recently demonstrated that Aurora-A kinase is a potential oncogene to develop mammary gland tumors in mice, when expressed under MMTV promoter. These tumors contain phosphorylated forms of Akt and mTOR, suggesting that Akt-mTOR pathway is involved in transformed phenotype induced by Aurora-A. In the present studies, we discovered that stable cell lines expressing Aurora-A contain phosphorylation of Akt...

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Identifiers

PMID: 19564927
DOI: 10.7150/ijbs.5.444
PMCID: PMC2702827

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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