Article
Serrated neoplasia in the colorectum: gut microbiota and molecular pathways.
Gut microbes - 1 Jan 2000
Kang Xing, Zhang Ru, Kwong Thomas Ny, Lui Rashid Ns, Wu William Kk, Sung Joseph Jy, Yu Jun, Wong Sunny H
Abstract excerpt
Colorectal cancer (CRC) is a heterogeneous disease with different gene expression patterns. There are two major colorectal carcinogenesis pathways: conventional adenoma-carcinoma pathway and alternative serrated neoplasia pathway. Apart from the conventional pathway that is typically initiated by characteristic APC mutation and chromosomal instability, the serrated neoplasia pathway is mainly characterized by...
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