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Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation

23 Jun 2022

Abstract excerpt

Abstract Type II collagen-positive (Col2+) cells have been reported as skeletal stem cells (SSCs), but the contribution of Col2+ progenitors to skeletal development both prenatally and postnatally during aging remains unclear. To address this question, we generated new mouse models with ablation of Col2+ cells at either the embryonic or postnatal stages. The embryonic ablation of Col2+ progenitors resulted in the...

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PMID: 35739091
DOI: 10.1038/s41413-022-00214-z

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