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Article

Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2012

Wosczyna Michael N, Biswas Arpita A, Cogswell Catherine A, Goldhamer David J

Abstract excerpt

Heterotopic ossification is a debilitating condition that can result from traumatic injury, surgery, or genetic disease. We investigated the cellular origins of heterotopic skeletogenesis in the mouse using lineage tracing and bioassays of heterotopic ossification based on intramuscular transplantation. We identified, characterized, and purified a tissue-resident stem/progenitor cell population that exhibits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ossification, Heterotopic

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Source

Open in PubMed Open full text

Identifiers

PMID: 22307978
DOI: 10.1002/jbmr.1562
PMCID: PMC3361573

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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