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Article

Macrophage phenotype and function are dependent upon the composition and biomechanics of the local cardiac tissue microenvironment.

Aging - 17 May 2021

Haschak Martin, LoPresti Samuel, Stahl Elizabeth, Dash Siddhartha, Popovich Branimir, Brown Bryan N

Abstract excerpt

Macrophage accumulation and nitrosative stress are known mechanisms underlying age-related cardiovascular pathology and functional decline. The cardiac muscle microenvironment is known to change with age, yet the direct effects of these changes have yet to be studied in-depth. The present study sought to better elucidate the role that biochemical and biomechanical alterations in cardiac tissue have in the altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34292877
DOI: 10.18632/aging.203054
PMCID: PMC8312435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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