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Article

Role of macrophages in regression of myocardial fibrosis following alleviation of left ventricular pressure overload.

American journal of physiology. Heart and circulatory physiology - 1 May 2024

Neff Lily S, Biggs Rachel M, Zhang Yuhua, Van Laer An O, Baicu Catalin F, Subramanian Suganya, Berto Stefano, DeLeon-Pennell Kristine, Zile Michael R, Bradshaw Amy D

Abstract excerpt

Sustained hemodynamic pressure overload (PO) produced by murine transverse aortic constriction (TAC) causes myocardial fibrosis; removal of TAC (unTAC) returns left ventricle (LV) hemodynamic load to normal and results in significant, but incomplete regression of myocardial fibrosis. However, the cellular mechanisms that result in these outcomes have not been defined. The objective was to determine temporal...

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Identifiers

PMID: 38363214
DOI: 10.1152/ajpheart.00240.2023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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