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Article

Epigenetic reprogramming to prevent genetic cardiomyopathy.

The Journal of clinical investigation - 4 Jan 2021

Johnston Jamie R, Selgrade Daniel F, McNally Elizabeth M

Abstract excerpt

Mutations in the gene that codes for lamin A/C (LMNA) are a common cause of adult-onset cardiomyopathy and heart failure. In this issue of the JCI, Guénantin and Jebeniani et al. identify impaired cardiomyocyte development and maturation as a prenatal feature in a model of laminopathy. Cardiomyocytes carrying the Lmna point mutation H222P misexpressed genes involved in the epithelial-mesenchymal transition and...

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Identifiers

PMID: 33393498
DOI: 10.1172/JCI143684
PMCID: PMC7773388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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