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Article

Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.

The Journal of cell biology - 21 Jan 2002

Gladfelter Amy S, Bose Indrani, Zyla Trevin R, Bardes Elaine S G, Lew Daniel J

Abstract excerpt

At the beginning of the budding yeast cell cycle, the GTPase Cdc42p promotes the assembly of a ring of septins at the site of future bud emergence. Here, we present an analysis of cdc42 mutants that display specific defects in septin organization, which identifies an important role for GTP hydrolysis by Cdc42p in the assembly of the septin ring. The mutants show defects in basal or stimulated GTP hydrolysis, and...

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Identifiers

PMID: 11807094
DOI: 10.1083/jcb.200109062
PMCID: PMC2199227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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