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Article

Mitochondrial DNA haplogroup M7 confers a reduced risk of colorectal cancer in a Han population from northern China.

Journal of cellular and molecular medicine - 1 Aug 2021

Yuan Qing, Su Liping, Wang Tian, Liu Yang, Lu Zhenxing, Zhou Kaixiang, Guo Shanshan, Gu Xiwen, Xing Jinliang, Guo Xu

Abstract excerpt

Mitochondria are central eukaryotic organelles in cellular metabolism and ATP production. Mitochondrial DNA (mtDNA) alterations have been implicated in the development of colorectal cancer (CRC). However, there are few reports on the association between mtDNA haplogroups or single nucleotide polymorphisms (SNPs) and the risk of CRC. The mtDNA of 286 Northern Han Chinese CRC patients were sequenced by...

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PMID: 34288389
DOI: 10.1111/jcmm.16789
PMCID: PMC8335663

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