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Genetic variations of mitochondrial genome modify risk and prognosis of hepatocellular carcinoma patients.

Clinics and research in hepatology and gastroenterology - 1 Sept 2017

Chen Cheng, Ba Yanna, Li Deyang, Du Xiaohong, Lia Xin, Yang Hai, An Jiaze, Xing Jinliang, Yang Hushan, Dong Guanglong, Guo Xu

Abstract excerpt

BACKGROUND: Previous studies have indicated that mitochondrial genetic variations were associated with the risk of many cancers. However, there are few reports on the association between single nucleotide polymorphisms (SNPs) or haplogroups of mitochondrial DNA (mtDNA) and the risk or prognosis of hepatocellular carcinoma (HCC). METHODS: In order to investigate the predictive and prognostic role of mtDNA SNPs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28215537
DOI: 10.1016/j.clinre.2016.12.002

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