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Article

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2021

Rotgers Emmi, Nicol Barbara, Rodriguez Karina, Rattan Saniya, Flaws Jodi A, Yao Humphrey Hung-Chang

Abstract excerpt

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes in the pituitary and impaired development of...

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PMID: 34288113
DOI: 10.1096/fj.202100304R
PMCID: PMC8299866

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