Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome wide expression analysis of radiation-induced DNA damage responses in isogenic HCT116 p53+/+ and HCT116 p53-/- colorectal carcinoma cell lines.

International journal of radiation biology - 1 Jan 2015

Lindgren Theres, Stigbrand Torgny, Råberg Aino, Riklund Katrine, Johansson Lennart, Eriksson David

Abstract excerpt

PURPOSE: To study the kinetics of gene expression alterations following radiation exposure of isogenic HCT116 p53 +/+ and HCT116 p53-/- cell lines. MATERIALS AND METHODS: Cells were exposed to 5 Gy of irradiation (Cs-137) and genome-wide temporal expression analysis using Illumina bead chip arrays was performed. Signalling pathways were explored using Metacore (Genego). Biological responses including cell cycle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Centrosome

Share to DNA Damage

Share to Dose-Response Relationship, Radiation

Share to HCT116 Cells

Share to Mitosis

Source

Identifiers

PMID: 25219679
DOI: 10.3109/09553002.2015.959668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome wide expression analysis of radiation-induced DNA damage responses in isogenic HCT116 p53+/+ and HCT116 p53-/- colorectal carcinoma cell lines.PMID 25219679Read ↗

Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalitiesSemantic proximity Read ↗

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.Semantic proximity Read ↗

Cellular Response to Chemoradiotherapy, Radiotherapy and Chemotherapy in Two Colorectal Cancer Cell LinesSemantic proximity Read ↗

Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cellsSemantic proximity Read ↗

Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer TherapySemantic proximity Read ↗

A genetic basis for the variation in the vulnerability of cancer to DNA damageSemantic proximity Read ↗

Transcriptional modulation induced by ionizing radiation: p53 remains a central playerSemantic proximity Read ↗

Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer TherapySemantic proximity Read ↗

High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer DevelopmentSemantic proximity Read ↗

The Role of p53 Mutations in Early and Late Response to Mitotic Aberrations.Semantic proximity Read ↗

Characterization of Intrinsic Radiation Sensitivity in a Diverse Panel of Normal, Cancerous and CRISPR-Modified Cell LinesSemantic proximity Read ↗

Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.