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Article

Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemia.

Oncotarget - 16 Aug 2016

Migliavacca Jessica, Percio Stefano, Valsecchi Roberta, Ferrero Elisabetta, Spinelli Antonello, Ponzoni Maurilio, Tresoldi Cristina, Pattini Linda, Bernardi Rosa, Coltella Nadia

Abstract excerpt

Hypoxia inducible transcription factors (HIFs) are the main regulators of adaptive responses to hypoxia and are often activated in solid tumors, but their role in leukemia is less clear. In acute myeloid leukemia (AML), in particular, controversial new findings indicate that HIF-1α can act either as an oncogene or a tumor suppressor gene, and this may depend on the stage of leukemia development and/or the AML...

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Identifiers

PMID: 27447550
DOI: 10.18632/oncotarget.10660
PMCID: PMC5288204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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