Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.

doi:10.1038/s41467-021-24570-2

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Article

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.

Nature communications - 16 Jul 2021

Zhao Zhe, Wang Huimeng, Shi Mai, Zhu Tianyuan, Pediongco Troi, Lim Xin Yi, Meehan Bronwyn S, Nelson Adam G, Fairlie David P, Mak Jeffrey Y W, Eckle Sidonia B G, de Lima Moreira Marcela, Tumpach Carolin, Bramhall Michael, Williams Cameron G, Lee Hyun Jae, Haque Ashraful, Evrard Maximilien, Rossjohn Jamie, McCluskey James, Corbett Alexandra J, Chen Zhenjun

Abstract excerpt

Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cells has been demonstrated in murine models of local infection, including in the lungs. Here we show that during systemic infection of mice with Francisella tularensis live vaccine strain results in evident MAIT cell expansion in the liver, lungs, kidney and spleen and peripheral blood....

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PMID: 34272362
DOI: 10.1038/s41467-021-24570-2
PMCID: PMC8285429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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