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Article

Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia.

Infection and immunity - 1 Apr 2006

Pammit Michael A, Raulie Erin K, Lauriano Crystal M, Klose Karl E, Arulanandam Bernard P

Abstract excerpt

Francisella tularensis is an intracellular gram-negative bacterium that is the causative agent of tularemia and a potential bioweapon. We have characterized the efficacy of a defined F. novicida mutant (DeltaiglC) as a live attenuated vaccine against subsequent intranasal challenge with the wild-type organism. Animals primed with the F. novicida DeltaiglC (KKF24) mutant induced robust splenic gamma interferon...

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Source

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Identifiers

PMID: 16552035
DOI: 10.1128/IAI.74.4.2063-2071.2006
PMCID: PMC1418901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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