Article
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons.
Nature communications - 1 Jul 2021
Lou Min-Min, Tang Xiao-Qiang, Wang Guang-Ming, He Jia, Luo Fang, Guan Ming-Feng, Wang Fei, Zou Huan, Wang Jun-Ying, Zhang Qun, Xu Ming-Jian, Shi Qi-Li, Shen Li-Bing, Ma Guo-Ming, Wu Yi, Zhang Yao-Yang, Liang Ai-Bin, Wang Ting-Hua, Xiong Liu-Lin, Wang Jian, Xu Jun, Wang Wen-Yuan
Abstract excerpt
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we report and characterize a lncRNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system. BS-DRL1 is a brain-specific lncRNA and...
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