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Article

YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

17 Jan 2019

Abstract excerpt

RATIONALE: The Hippo pathway governs cellular differentiation, morphogenesis, and homeostasis, but how it regulates these processes in lymphatic vessels is unknown. OBJECTIVE: We aimed to reveal the role of the final effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), in lymphatic endothelial cell (LEC) differentiation, morphogenesis, and...

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Identifiers

PMID: 30582452
DOI: 10.1161/circresaha.118.313707

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