Article
A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes.
Med (New York, N.Y.) - 9 Jul 2021
Schneider Carolin V, Schneider Kai Markus, Conlon Donna M, Park Joseph, Vujkovic Marijana, Zandvakili Inuk, Ko Yi-An, Trautwein Christian, Center Regerneron, Carr Rotonya M, Strnad Pavel, Thaiss Christoph A, Rader Daniel J
Abstract excerpt
BACKGROUND: A coding variant in MTARC1 (rs2642438; p.Ala165Thr) was recently associated with protection from cirrhosis in European individuals. However, its impact on overall and cause-specific mortality remained elusive. METHODS: Using a genome-first approach, we explored a range of metabolic phenotypes and outcomes associated with MTARC1 p.Ala165Thr in the UKBiobank and the Penn-Medicine BioBank. FINDINGS:...
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