Article
A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.
Hepatology communications - 1 May 2024
Hehl Leonida, Creasy Kate T, Vitali Cecilia, Scorletti Eleonora, Seeling Katharina S, Vell Mara S, Rendel Miriam D, Conlon Donna, Vujkovic Marijana, Zandvakili Inuk, Trautwein Christian, Schneider Kai M, Rader Daniel J, Schneider Carolin V
Abstract excerpt
BACKGROUND: Common variants of the max-like protein X (MLX)-interacting protein-like (MLXIPL) gene, encoding the transcription factor carbohydrate-responsive element-binding protein, have been shown to be associated with plasma triglyceride levels. However, the role of these variants in steatotic liver disease (SLD) is unclear. METHODS: We used a genome-first approach to analyze a variety of metabolic phenotypes...
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