Article
MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.
Oncogene - 1 Apr 2020
Yang William, Khoury Elie, Guo Qianyu, Prabhu Sathyen A, Emond Audrey, Huang Fan, Gonçalves Christophe, Zhan Yao, Plourde Dany, Nichol Jessica N, Dahabieh Michael S, Miller Wilson H, Del Rincón Sonia Victoria
Abstract excerpt
The BRAFV600E mutation occurs in more than 50% of cutaneous melanomas, and results in the constitutive activation of the mitogen-activated protein kinases (MAPK) pathway. MAP kinase-interacting serine/threonine-protein kinase 1 and 2 (MNK1/2) are downstream effectors of the activated MAPK pathway, and important molecular targets in invasive and metastatic cancer. Despite the well-known role of MNK1 in regulating...
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