Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants.

JCO precision oncology - 1 Jan 2021

Modlin Leslie A, Flynn Jessica, Zhang Zhigang, Cahlon Oren, Mueller Boris, Khan Atif J, Gillespie Erin F, McCormick Beryl, Stadler Zsofia K, Robson Mark E, Powell Simon N, Braunstein Lior Z

Abstract excerpt

ATM, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). ATM PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant radiotherapy (RT) may cause excess morbidity among heterozygous carriers of ATM PV. We evaluated the tolerability of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genetic Variation

Share to Germ Cells

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 34250389
DOI: 10.1200/PO.20.00334
PMCID: PMC8232182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants.PMID 34250389Read ↗

The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.Semantic proximity Read ↗

Ataxia-telangiectasia gene (ATM) mutation heterozygosity in breast cancer: a narrative review.Semantic proximity Read ↗

ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment RecommendationsSemantic proximity Read ↗

Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM.Semantic proximity Read ↗

Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers.Semantic proximity Read ↗

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.Semantic proximity Read ↗

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.Semantic proximity Read ↗

Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy.Semantic proximity Read ↗

Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.Semantic proximity Read ↗

Possession of ATM Sequence Variants as Predictor for Late Normal Tissue Responses in Breast Cancer Patients Treated With RadiotherapySemantic proximity Read ↗

Rare variants in the ATM gene and risk of breast cancer.Semantic proximity Read ↗

ATM, radiation, and the risk of second primary breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.