Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers.

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Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2002

Offit Kenneth, Gilad Shlomit, Paglin Shoshana, Kolachana Prema, Roisman Laila C, Nafa Khedoudja, Yeugelewitz Vincent, Gonzales Maria, Robson Mark, McDermott Deborah, Pierce Heather Hanson, Kauff Noah D, Einat Paz, Jhanwar Suresh, Satagopan Jaya M, Oddoux Carole, Ellis Nathan, Skaliter Rami, Yahalom Joachim

Abstract excerpt

PURPOSE: In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin's disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers. EXPERIMENTAL DESIGN: Full sequence...

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PMID: 12473594

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