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Article

Mutations in BRCA1, BRCA2, and PALB2, and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma.

Scientific reports - 25 May 2018

Takeuchi Shoko, Doi Manami, Ikari Naoki, Yamamoto Masakazu, Furukawa Toru

Abstract excerpt

Mutations in genes of the breast cancer susceptibility gene (BRCA) pathway, namely, BRCA1, BRCA2, and PALB2, can provide useful information for the efficacy of platinum-based or poly ADP-ribose polymerase inhibitors chemotherapeutic regimens. Pancreatic ductal adenocarcinoma (PDAC) is an important target for such precision chemotherapies because of its dismal prognosis. We analyzed mutations in the entire coding...

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Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to PALB2 gene

Share to SMARCB1 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 29802286
DOI: 10.1038/s41598-018-26526-x
PMCID: PMC5970161

Genes

BRCA2
BRCA1
PALB2
GNAS
KRAS
MLH1
SMAD4
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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