Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2018

Sehdev Amikar, Gbolahan Olumide, Hancock Brad A, Stanley Melissa, Shahda Safi, Wan Jun, Wu Howard H, Radovich Milan, O'Neil Bert H

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX. EXPERIMENTAL DESIGN: Indiana University Simon Cancer Center pancreatic cancer database was used to identify patients with metastatic PDAC, treated with FOLFIRINOX and had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorouracil
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA2

Share to Irinotecan

Share to Kaplan-Meier Estimate

Share to Leucovorin

Share to Oxaliplatin

Share to Pancreatic Neoplasms

Source

Identifiers

PMID: 30131383
DOI: 10.1158/1078-0432.CCR-18-1472

Genes

BRCA1
BRCA2
FANCF
MSH2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX.PMID 30131383Read ↗

DNA damage repair deficiency as a predictive biomarker for FOLFIRINOX efficacy in metastatic pancreatic cancerSemantic proximity Read ↗

Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer.Semantic proximity Read ↗

An Emerging Paradigm for Germline Testing in Pancreatic Ductal Adenocarcinoma and Immediate Implications for Clinical Practice: A Review.Semantic proximity Read ↗

Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma.Semantic proximity Read ↗

Germline Aberrations in Pancreatic Cancer: Implications for Clinical CareSemantic proximity Read ↗

Germline mutations in pancreatic cancer and potential new therapeutic optionsSemantic proximity Read ↗

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as BiomarkersSemantic proximity Read ↗

DNA Repair Dysfunction in Pancreatic Cancer: A Clinically Relevant Subtype for Drug Development.Semantic proximity Read ↗

Management of BRCA Mutation Carriers With Pancreatic Adenocarcinoma.Semantic proximity Read ↗

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.