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Article

Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway

8 Oct 2022

Abstract excerpt

The role of autophagy in cancer is context-dependent. In the present study, we aimed to investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin (SIRT) family member, SIRT4, was significantly associated autophagy pathway in pancreatic ductal adenocarcinoma (PDAC). Specifically, in vitro cell culture experiments and in vivo transgenic and xenografted animal models revealed that...

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PMID: 36209169
DOI: 10.1038/s41418-022-01063-3

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