Article
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
PloS one - 1 Jan 2021
Li Zhen, Zhang Ji, Zou Wei, Xu Qi, Li Siyuan, Wu Jie, Zhu Li, Zhang Yunjiao, Xu Lei, Zhang Ying, Luo Qingsong, Nie Jianyun, Li Xingxu, Zou Tianning, Chen Ceshi
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or...
Topics
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Female
- China
- Genetic Predisposition to Disease
- Middle Aged
- Polymorphism, Single Nucleotide
- Breast Neoplasms
- Adult
- Triple Negative Breast Neoplasms