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Article

V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity.

Journal of virology - 26 Jul 2021

Ou Junxian, Zhou Zhonghua, Dai Ruixue, Zhang Jing, Zhao Shan, Wu Xiaowei, Lan Wendong, Ren Yi, Cui Lilian, Lan Qiaoshuai, Lu Lu, Seto Donald, Chodosh James, Wu Jianguo, Zhang Gong, Zhang Qiwei

Abstract excerpt

The current pandemic of COVID-19 is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein receptor-binding domain (RBD) is the critical determinant of viral tropism and infectivity. To investigate whether naturally occurring RBD mutations during the early transmission phase have altered the receptor binding affinity and infectivity, we first...

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Identifiers

PMID: 34105996
DOI: 10.1128/JVI.00617-21
PMCID: PMC8373230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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