Article
Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.
Genes and immunity - 1 Jan 2006
Zheng W, Rosenstiel P, Huse K, Sina C, Valentonyte R, Mah N, Zeitlmann L, Grosse J, Ruf N, Nürnberg P, Costello C M, Onnie C, Mathew C, Platzer M, Schreiber S, Hampe J
Abstract excerpt
Linkage analyses have implicated chromosome 7p21.3 as a susceptibility region for inflammatory bowel disease (IBD). Recently, the mouse phenotype with diarrhea and goblet cell dysfunction caused by anterior gradient protein 2 dysfunction was reported (European patent WO2004056858). The genes encoding for the human homologues AGR2 and AGR3 are localized on chromosome 7p21.3. The gene structures were verified and...
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