Article
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.
Nature communications - 7 Jul 2021
Nishii Rina, Mizuno Takanori, Rehling Daniel, Smith Colton, Clark Brandi L, Zhao Xujie, Brown Scott A, Smart Brandon, Moriyama Takaya, Yamada Yuji, Ichinohe Tatsuo, Onizuka Makoto, Atsuta Yoshiko, Yang Lei, Yang Wenjian, Thomas Paul G, Stenmark Pål, Kato Motohiro, Yang Jun J
Abstract excerpt
Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently, diphosphatase NUDT15 was linked to thiopurine metabolism with NUDT15 polymorphism associated with drug toxicity in patients. Profiling NNA drugs, we identify acyclovir (ACV) and ganciclovir (GCV) as two new NNAs metabolized by NUDT15....
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