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Article

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.

EMBO reports - 1 May 2016

Groh Beezly S, Yan Feng, Smith Matthew D, Yu Yanbao, Chen Xian, Xiong Yue

Abstract excerpt

WDTC1/Adp encodes an evolutionarily conserved suppressor of lipid accumulation. While reduced WDTC1 expression is associated with obesity in mice and humans, its cellular function is unknown. Here, we demonstrate that WDTC1 is a component of a DDB1-CUL4-ROC1 (CRL4) E3 ligase. Using 3T3-L1 cell culture model of adipogenesis, we show that disrupting the interaction between WDTC1 and DDB1 leads to a loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27113764
DOI: 10.15252/embr.201540500
PMCID: PMC5341520

Genes

DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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