Article
Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.
Cancer metastasis reviews - 1 Sept 2016
Boscolo-Rizzo Paolo, Da Mosto Maria Cristina, Rampazzo Enrica, Giunco Silvia, Del Mistro Annarosa, Menegaldo Anna, Baboci Lorena, Mantovani Monica, Tirelli Giancarlo, De Rossi Anita
Abstract excerpt
Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a frequently lethal, heterogeneous disease whose pathogenesis is a multistep and multifactorial process involving genetic and epigenetic events. The majority of HNSCC patients present with locoregional advanced stage disease and are treated with...
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