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Article

Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.

Gastroenterology - 1 Feb 2014

Gala Manish K, Mizukami Yusuke, Le Long P, Moriichi Kentaro, Austin Thomas, Yamamoto Masayoshi, Lauwers Gregory Y, Bardeesy Nabeel, Chung Daniel C

Abstract excerpt

BACKGROUND & AIMS: Little is known about the genetic factors that contribute to the development of sessile serrated adenomas (SSAs). SSAs contain somatic mutations in BRAF or KRAS early in development. However, evidence from humans and mouse models indicates that these mutations result in oncogen...

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Source

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Identifiers

PMID: 24512911
DOI: 10.1053/j.gastro.2013.10.045
PMCID: PMC3978775

Genes

ATM
RNF43
ATR
BRAF
KRAS
PIF1
RBL1
TELO2
XAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24512911-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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