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Article

Circulating CD4+ FoxP3- CXCR5- CXCR3+ PD-1hi cells are elevated in active rheumatoid arthritis and reflect the severity of the disease.

International journal of rheumatic diseases - 1 Aug 2021

Zhao Lei, Li Zhenxue, Zeng Xingyue, Xia Changsheng, Xu Lijuan, Xu Qinzhu, Song Ying, Liu Chen

Abstract excerpt

OBJECTIVE: To examine the expression and clinical significance of circulating CD4+ FoxP3- CXCR5- CXCR3+ PD-1hi cells in rheumatoid arthritis (RA). METHODS: CD4+ FoxP3- CXCR5- CXCR3+ PD-1hi cells in peripheral blood of 35 patients with active RA, 17 with RA in stable remission, and 24 healthy controls were analyzed by flow cytometry. Serum IgG and circulating plasmablast percentages were measured and...

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PMID: 34227243
DOI: 10.1111/1756-185X.14170

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